Custom Chemical Synthesis and Manufacturing Services
Custom Chemical Synthesis Built Around Your Project
When a molecule, process, or production requirement does not fit a standard catalog or a single manufacturing site, Richman Chemical Inc. (RCI) provides a more flexible path. RCI coordinates custom chemical synthesis, process development, scale-up, and manufacturing by matching each project with the technical expertise, equipment, quality environment, location, and production scale it requires.
From proof-of-concept quantities and route verification to pilot campaigns and recurring commercial production, RCI gives customers one experienced project team across the program. The result is a practical outsourcing model designed to reduce coordination burden, preserve technical continuity, and support successful commercialization.
Why Companies Choose RCI for Custom Synthesis
Traditional contract manufacturers typically work within the limits of their installed equipment, available capacity, and preferred chemistry. RCI begins with the project requirements and identifies an appropriate production solution around them.
Project-specific technical fit
Chemistry, equipment, containment, scale, quality, geography, timing, and cost requirements are considered when configuring the program.
One point of accountability
RCI provides a central commercial and project-management interface across development, transfer, manufacturing, and supply activities.
Scale flexibility
Programs can move from initial laboratory quantities to pilot preparation and commercial manufacture as requirements evolve.
Broad chemistry access
RCI supports organic, inorganic, organometallic, polymer, electronic, chiral, and other specialty chemistry needs through appropriately aligned resources.
Commercialization focus
The engagement can extend beyond synthesis to process development, scale-up optimization, raw-material sourcing, packaging, documentation, and supply-chain coordination.
Flexible manufacturing network
Projects are not restricted to one fixed equipment set or production location, allowing the manufacturing strategy to adapt to the program.
From Concept to Commercial Supply
Custom Synthesis Capabilities
RCI evaluates each request individually and coordinates resources appropriate to the molecule, process, scale, and end market.
Synthetic Chemistry
Complex multi-step organic synthesis
Small-molecule and advanced intermediate synthesis
Inorganic and organometallic chemistry
Polymerizations, custom monomers, and specialty polymers
Chiral synthesis and resolution
Reference compounds, impurities, and final targets
Process and Analytical Support
Route scouting and route selection
Process design, development, and optimization
Scale-up and manufacturing-readiness assessment
Analytical method development and validation
Impurity isolation and characterization
Process validation and transfer support
Specialized Processing Environments
Air-sensitive or difficult-to-handle materials
Energetic chemistry and extreme reaction conditions
High-pressure and high-temperature processing
Specialized materials of construction
HPAPI or cytotoxic manufacturing when required
Electronic-grade and tightly controlled specialty materials
Manufacturing and Unit Operations
Blending, extraction, and distillation
Polymer processing
Particle-size modification and solids handling
Drying, agglomeration, coating, and granulation
Repackaging of liquids and solids
Pilot and full-scale custom manufacturing
Compliance and Market Requirements
Custom synthesis programs may require different quality and regulatory environments depending on the intended application. RCI considers end-use and documentation requirements when identifying and coordinating an appropriate manufacturing pathway.
Pharmaceutical cGMP
Food cGMP and food-grade requirements
ISO-based manufacturing environments
Kosher requirements
DEA-controlled substance capabilities when applicable
DMF preparation and pharmaceutical documentation support
HPAPI and cytotoxic handling requirements
Application-specific quality and testing expectations
Final capabilities, certifications, and documentation are confirmed for the selected project and manufacturing resource before work begins.
Markets Served
The RCI Business Model
RCI operates as an independent, network-based custom chemistry and manufacturing partner. Instead of requiring every project to fit a single site, RCI identifies and coordinates resources based on the specific technical and commercial requirements of the program.
What to Include in a Custom Synthesis Inquiry
A concise initial project description helps RCI determine fit and identify the right next step. Confidential technical details can be addressed through an appropriate confidentiality agreement.
Target molecule or general chemistry description
Current route, literature reference, or available process information
Required quantity and expected future scale
Target specifications, analytical methods, or quality requirements
Intended application and regulatory or compliance expectations
Required timing and key commercial milestones
Known safety, handling, containment, or equipment considerations
Preferred manufacturing geography, if applicable
START A CONFIDENTIAL PROJECT DISCUSSION Contact Richman Chemical at (215) 628-2946 or click the button below to discuss chemistry, specifications, scale, quality requirements, and timing.
Compliance Offerings:
HPAPI and Cytotoxic manufacturing
cGMP (pharmaceutical)
cGMP (food)
DEA license
DMF preparation
Food Grade
Kosher
ISO 900x
Reaction Capabilities:
Alkylation
Amidation
Bromination
Chiral Resolution/Custom Synthesis
Condensation
Cyanoethlyation
Dehydrohalogenation
Diazotization
Enzymatic Custom Synthesis
Esterification
Ethoxylation
Fluorination
Hydrogenation
Nitration
Oxidation
Organometallic Custom Synthesis
Phosgenation
Phosphation
Polymerization
Quaternization
Reductive Amination
Sulfonation
Scales:
Small Scale Custom Synthesis (mg to kg)
Pilot Scale Preparation (kg)
Full Scale Manufacture (kg to millions of pounds)